What Is Hepatic Adenoma?
Hepatobiliary carcinomas are benign tumors that develop from bile ducts. They may affect any part of the body, but they most commonly occur in the liver, spleen, gallbladder or pancreas. The majority of cases arise during pregnancy and result in no symptoms at all. However, some patients with hepatocellular carcinomas have symptoms such as nausea, vomiting or abdominal pain.
In rare instances, these tumors can cause life-threatening complications including acute pancreatitis (inflammation of the pancreas), jaundice (yellowing of the skin and eyes) and even death. These types of cancers are called non-alcoholic fatty liver disease (NAFLD). NAFLD is a major health problem worldwide.
The incidence of hepatocellular carcinomas increases during childhood and adolescence. About one-third of young adults will develop hepatocellular carcinoma in their lifetime. Some studies suggest that children born to obese mothers are more likely to develop hepatocellular carcinoma than those born to normal weight women.
Hepatobiliary cancer is the second leading cause of cancer deaths among men and women aged 15–24 years, after lung cancer. It is also the fifth most common cause of cancer-related death in the world.
There are two main types of hepatic adenomas:
Focal nodular hyperplasia (FNH) is a benign liver growth in which cells grow at an abnormal, explosive rate. Focal nodular hyperplasia only affects the liver, and most people without significant alcohol use do not have this condition.
Focal nodular hyperplasia is sometimes called “benign” because it rarely spreads to other organs or becomes cancerous. It is, however, capable of causing the death of the person in which it affects.
Focal nodular hyperplasia most often appears in people under the age of 50 and is more common in men than in women. Focal nodular hyperplasia usually causes no symptoms unless it grows large enough to restrict the flow of bile.
The cause of this condition is unknown. However, long-term use of certain antiviral drugs used to treat the hepatitis C virus has been linked to the development of FNH in some patients.
Oncocerciasis is a disease caused by Onchocerca volvulus, a parasitic roundworm that infects about 37 million people worldwide. Onchocerciasis is a skin disease that causes intense itching, visual impairment and eye lesions.
Sources & references used in this article:
Hepatic adenoma and focal nodular hyperplasia. by CK Shortell, SI Schwartz – Surgery, gynecology & obstetrics, 1991 – ncbi.nlm.nih.gov
Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic, and radiologic features by P Kerlin, GL Davis, DB McGill, LH Weiland, MA Adson… – Gastroenterology, 1983 – Elsevier
Focal nodular hyperplasia and hepatic adenoma: comparison of angiography, CT, US, and scintigraphy. by TJ Welch, PF Sheedy 2nd, CM Johnson, DH Stephens… – Radiology, 1985 – pubs.rsna.org