Tramadol, Oral Tablet

Tramadol is a medication which was developed in Germany in the early 1970’s. It was originally designed to treat pain associated with cancer chemotherapy. Since then it has been approved for various other conditions such as chronic pain, depression, anxiety disorders, and insomnia. However, it is most commonly prescribed off label (used outside its original intended use) for treating moderate to severe pain from injuries or surgery.

The drug is available in several strengths ranging from 25 mg to 200 mg. There are two main types of tramadol: extended release tablets and immediate release capsules. Extended release tablets contain 50% more active ingredient than regular tablets, while immediate release capsules contain 75% less active ingredient than regular capsules.

Tramadol has been shown to have analgesic properties similar to morphine but without the risk of addiction. Its mechanism of action involves blocking the reuptake of noradrenaline, serotonin, and dopamine. These neurotransmitters are responsible for many physiological functions including mood regulation, appetite control, sleepiness/insomnia, nausea and vomiting, cardiovascular function and pain perception.

Side Effects of Tramadol

There are no known significant adverse effects associated with tramadol at any dose level. There are also no serious adverse effects known at this time. In fact, the most common side effect reported with tramadol is mild nausea, which should subside in a day or two.

Sources & references used in this article:

… -dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets, and placebo after oral … by JR Fricke Jr, R Karim, D Jordan, N Rosenthal – Clinical therapeutics, 2002 – Elsevier

… double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of … by …, A Orlando, JV Winkler, Tramadol ODT Study Group – European urology, 2012 – Elsevier

An evaluation of the efficacy and tolerability of oral tramadol hydrochloride tablets for the treatment of postsurgical pain in children by JC Finkel, JB Rose, ML Schmitz… – Anesthesia & …, 2002 –

Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study by M Giorgi, G Saccomanni… – The Veterinary …, 2009 – Elsevier

Tramadol/paracetamol by K McClellan, LJ Scott – Drugs, 2003 – Springer

Formulation optimization of hydrodynamically balanced oral controlled release bioadhesive tablets of tramadol hydrochloride by B Singh, A Rani, N Ahuja, R Kapil – Scientia pharmaceutica, 2010 –

Use of tramadol in children by P Bozkurt – Pediatric Anesthesia, 2005 –

Pharmacokinetics and antinociceptive effects of oral tramadol hydrochloride administration in Greyhounds by B KuKanich, MG Papich – American journal of veterinary …, 2011 – Am Vet Med Assoc

Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride by J Varshosaz, N Tavakoli, F Kheirolahi – Aaps Pharmscitech, 2006 – Springer