Propafenone, Oral Tablet

Propafenone Side Effects:

The following are some of the possible side effects associated with taking Propafenone, orally tablet. You should always speak to your doctor or pharmacist before starting any new medication.

Common Side Effects:

Nausea (vomiting) – This is one of the most common side effects experienced when using Propafenone, orally tablet. Symptoms include nausea and vomiting. If you experience these symptoms, it is best to stop taking Propafenone immediately and consult your doctor.

Weight Gain – Weight gain can occur if you do not eat enough during the day. Eating too much food will cause you to vomit which causes weight loss. You need to keep eating regularly while on Propafenone, otherwise you risk gaining weight.

Headache – Headaches are another symptom that occurs when taking Propafenone, orally tablet. These headaches usually last less than 24 hours. They may be mild or severe. Your doctor can prescribe pain killers such as Tylenol or Ibuprofen to help relieve the headache.

Diarrhea – Diarrhea is another symptom that occurs when taking Propafenone, orally tablet. Diarrhea is caused by dehydration due to vomiting or diarrhea from Propafenone side effects. Stop taking the medication immediately and consult with your doctor if you experience diarrhea while or after taking the drug.

Allergic Reactions:

As with any new medication you start, it is possible to experience an allergic reaction. The symptoms for an allergic reaction may include hives, swelling of the tongue, difficulty breathing, and low blood pressure. If you experience any of these symptoms, stop taking the medication immediately and consult a doctor.

The following are less common but potentially more severe side effects:

Confusion – This side effect may occur with a high fever. Confusion may also impair your ability to make good decisions, including whether or not you should take your medication.

Hearing Loss or Changes in Taste – If you experience hearing loss, tinnitus (ringing in the ears), or changes in taste, this is a possible side effect of taking the drug. This side effect usually goes away after you stop taking the medication but may be a permanent problem.

Severe Allergic Reactions – Rarely, life-threatening allergic reactions have occurred in a small number of people who have taken Propafenone, orally tablet. If you experience hives, difficulty breathing, or swelling of the mouth, tongue, or face, you should seek immediate medical attention. Do not take this medication if you have a known allergy to it or any of the ingredients in it. If you are unsure, speak to your doctor before taking.

Severe Liver Problems – The U.S. Food and Drug Administration (FDA) has received reports of severe liver damage in people who use propafenone for a long period of time. Call your doctor immediately if you have symptoms of liver problems: nausea, fatigue, itchy skin, very dark urine, loss of appetite for several days or more, or yellowing of the skin or eyes.

If you experience any other unusual or severe side effects while taking this medication, contact your doctor immediately.

What if I forget to take a dose?

If you forget to take your daily dose of propafenone, take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take a double dose.

What if I overdose?

An overdose of propafenone is possible, although not likely as the drug has some serious side effects. The most likely symptom of an overdose is a drop in blood pressure, which may cause dizziness, fainting, or even heart attack. Other symptoms include shortness of breath, nausea, vomiting, diarrhea, and seizures.

If you think you or someone else may have overdosed on this medicine seek immediate medical attention. A physician may administer activated charcoal to reduce absorption if the overdose was within one hour. Additionally, a respirator may be required to stabilize breathing.

What should I avoid while taking this medication?

You should avoid drinking alcohol while taking this medication. A single drink may cause a dangerous reaction in some people. In others, it may increase the risk for dangerous side effects. Even if you do not experience any side effects from an alcohol drink, your blood pressure will likely be severely lowered. This can be dangerous for your health.

Where should I keep this medication?

Keep this medication at room temperature and protect it from light and moisture.

Does this medication expire?

You should seek a new supply of this drug every few months since it does expire after a while. It should be safe to take even if it has expired, but the effect of the drug may wear off faster than usual.

What happens if I overdose?

Seek emergency medical attention immediately. Overdoses of this medication can be fatal. You may experience fainting, low blood pressure, chest pain, severely low heart rate, and seizures. Seek immediate medical attention if you notice any of these symptoms.

What should I tell my provider before I take this medication?

Before taking propafenone, tell your provider if you have any of the following:

liver disease

an unusual or allergic reaction to propafenone or other antiarrhythmics (heart medicines)

pregnant or trying to get pregnant


How should I take this medication?

Take this medication exactly as prescribed by your provider. You should take it with meals. Do not crush or chew the pills.

What are the possible interactions with this medication?

alprozalam, amiodarone, amphotericin B, and cholestyramine

mibefradil, procainamide, quinidine, and terfenadine

You should not take propafenone if you are taking any of the following medications:

What are the side effects of this medication?

Sources & references used in this article:

Investigations on the pharmacokinetics of propafenone in man. by M Hollmann, E Brode, D Hotz, S Kaumeier… – Arzneimittel …, 1983 –

Conversion of recent-onset atrial fibrillation by a single oral loading dose of propafenone or flecainide by A Capucci, G Boriani, GL Botto, T Lenzi, I Rubino… – The American journal of …, 1994 – Elsevier

Clinical pharmacology of propafenone: pharmacokinetics, metabolism and concentration-response relations by LA Siddoway, DM Roden, RL Woosley – The American Journal of …, 1984 – Elsevier

Propafenone for conversion of recent-onset atrial fibrillation: a controlled comparison between oral loading dose and intravenous administration by G Boriani, A Capucci, T Lenzi, M Sanguinetti… – Chest, 1995 – Elsevier

Long-term oral propafenone therapy for suppression of refractory symptomatic atrial fibrillation and atrial flutter by EM Antman, AD Beamer, C Cantillon… – Journal of the …, 1988 –

Propafenone by DWG Harron, RN Brogden – Drugs, 1987 – Springer