Phentermine (also known as Dihydrocodeine) is a central nervous system stimulant used to treat attention deficit hyperactivity disorder (ADHD). It was first synthesized in 1887 and it was later found to have anxiolytic effects. It is sold under several brand names including Adderall®, Ritalin® and Vyvanse®.
The drug is available in various strengths ranging from 5 mg to 50 mg. There are many different brands of the drug and they differ greatly in their effects, but all of them contain amphetamine or dextroamphetamine. The main active ingredient in these drugs is methylphenidate hydrochloride (Ritalin®), which acts as a central nervous system stimulant. Its mechanism of action involves increasing levels of dopamine and norepinephrine in the brain. These chemicals increase alertness and energy level.
They also cause feelings of euphoria and relaxation.
Effects of Phentermine on ADHD Symptoms:
There are no long term studies done on the effect of phentermine on children with ADHD symptoms, however there are some anecdotal reports that suggest it may help. However, more research needs to be conducted into this topic so please consult your doctor before using this medication if you suffer from ADHD symptoms. This medication has been approved by the Food and Drug Administration (FDA) for use in treating ADHD symptoms in both children and adults.
Uses of Phentermine:
Phentermine is used to treat obesity defined as a person weighing more than 20% more than they should. It can also be used for short periods of time to help break weight loss plateaus that may occur during very low calorie diets (VLCD).
How it works:
Phentermine is a sympathomimetic amine that works by stimulating receptors in the brain. These receptors are responsible for things like blood pressure, hunger and heart rate. It also increases the amount of dopamine in the brain which is responsible for things like motivation and reward. It is used most commonly in weight loss as it suppresses the appetite and increases metabolism slightly.
Phentermine can cause a number of side effects some of which are serious and should be reported to your doctor immediately. These can include:
? Difficulty sleeping
? Dry mouth or difficulty swallowing
? Headache, dizziness or restlessness
? Nausea, constipation or diarrhea
? Tingling of the skin or nervousness
? Rapid heartbeat or palpitations.
Sources & references used in this article:
Phentermine and Topiramate Extended Release (Qsymia™) by F Cameron, G Whiteside, K McKeage – Drugs, 2012 – Springer
Phentermine/Topiramate extended-release capsules (qsymia) for weight loss by DJ Lonneman Jr, JA Rey, BD McKee – Pharmacy and Therapeutics, 2013 – ncbi.nlm.nih.gov
Coadministration of canagliflozin and phentermine for weight management in overweight and obese individuals without diabetes: a randomized clinical trial by P Hollander, HE Bays, J Rosenstock… – Diabetes …, 2017 – Am Diabetes Assoc
The influence of diuretics on the excretion and metabolism of doping agents. II. Phentermine. by FT Delbeke, M Debackere – Arzneimittel-Forschung, 1986 – europepmc.org
Phentermine and topiramate for the management of obesity: a review by G Cosentino, AO Conrad, GI Uwaifo – Drug design, development …, 2013 – ncbi.nlm.nih.gov
Phentermine—resin or salt—there are differences by TC Coyne – Archives of Internal Medicine, 1997 – jamanetwork.com
Combination anorexiant drug therapy for obesity using phentermine and an SSRI drug by JM Anchors – US Patent 5,795,895, 1998 – Google Patents
Combination phentermine and topiramate extended release in the management of obesity by N Alfaris, AM Minnick, CM Hopkins… – Expert opinion on …, 2015 – Taylor & Francis
New antiobesity agents: lorcaserin (Belviq) and phentermine/topiramate ER (Qsymia) by G Shyh, A Cheng-Lai – Cardiology in review, 2014 – journals.lww.com