Nicotinamide Riboside: Benefits, Side Effects and Dosage

Nicotinamide Riboside (NR) is a naturally occurring substance found in plants such as tobacco, wheat, barley and other grains. It is one of the most abundant antioxidants in nature. NR has been used for centuries to treat various diseases including cancer, cardiovascular disease, diabetes mellitus and many others. Nicotinamide riboside is also known as N-nitroso compounds or N-Nitrosamines (NOC).

The benefits of Nicotinamide Riboside are numerous. It has been shown to improve blood circulation, reduce inflammation, increase energy levels and promote weight loss. These beneficial effects have led to its widespread use in the treatment of various conditions. However, there are some potential problems with using NR supplements such as adverse reactions from taking it or even cancer risks if taken at high doses.

Research has indicated that NR may interact with drugs and medications. There are several possible reasons why this might happen. Some of these include:

Drugs like aspirin, warfarin, methotrexate, cyclophosphamide and others may interfere with the absorption of nicotinamide riboside. If you take any medication that contains nitrates or nitrites then they could cause stomach upset or nausea.

This nutrient may lower blood sugar levels. People already taking medications for diabetes or low blood sugar should be wary of using it as a supplement.

Some studies have shown that this compound can interact with the body’s ability to breakdown Tylenol and other anti-inflammatory drugs like Advil.

Nicotinamide riboside has been linked to side effects like diarrhea, nausea, stomach pain and vomiting in some people. These effects are less likely to occur when using low doses of the supplement.

Some early studies have shown that this compound can lower blood pressure in certain people. Those with low blood pressure may need to be cautious or avoid it altogether. It is also important to note that other studies have not found any blood pressure lowering effects. More research is needed to determine if there is a link between nicotinamide riboside and blood pressure.

Nicotinamide riboside can also increase the risk of dehydration. This is especially a concern for people who have a problem controlling their body temperature. It is important to stay hydrated while taking nicotinamide riboside supplements.

Long term use of this supplement may be linked to an increase in the risk of developing some types of cancer. However, the scientific community is still divided on whether these results are significant or not. More studies are needed to determine long term effects.

Nicotinamide riboside has been linked to lowering HDL cholesterol levels in the blood. This could increase your risk of heart disease or stroke.

There is no recommended daily allowance (RDA) for nicotinamide riboside. In general most health experts recommend that nicotinamide riboside should be taken in quantities less than 500 mg per day.

Nicotinamide riboside is found in very small quantities in some foods. These include:

Beef liver


Cheddar cheese


There are no known side effects of nicotinamide riboside from food sources.

Nicotinamide riboside is available without a prescription in the United States. The FDA has not approved it as a drug to prevent or treat any conditions.

Nicotinamide riboside is regulated as a dietary supplement in the United States. This means that it does not require approval by the Food and Drug Administration (FDA) before it can be marketed or sold to consumers. Manufacturers are required to comply with FDA labeling guidelines, but do not need to provide the same level of evidence for safety and effectiveness that drugs are required to do.

Nicotinamide riboside is available as a supplement in pill or powder form. It is most commonly sold by online retailers or specialty stores that sell dietary supplements. The price may vary due to the brand, quality and quantity of nicotinamide riboside per container. It is sold under a variety of different names.

Nicotinamide riboside is most commonly used as a dietary supplement to promote well-being and enhance memory. It has also been studied in the treatment of several conditions including Alzheimer’s disease, fibromyalgia, diabetes and cancer. In some cases, nicotinamide riboside has shown promise in treating these conditions. However, the research is still ongoing.

Nicotinamide riboside is classified as a vitamin B3. It is also sometimes referred to as vitamin B3 or niacinamide riboside.

Nicotinamide riboside is a nutritional supplement that has shown promise in the treatment of a number of conditions. Nicotinamide riboside is not well-researched and some studies have found no effect from the supplement. There are some concerns about the long-term effects of nicotinamide riboside. At this time, nicotinamide riboside is not considered to be a vitamin or mineral essential to health.


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What is Nicotinamide Riboside?

Nicotinamide riboside is a naturally-occurring form of vitamin B3 that plays an important role in the production of energy. The ingredient has been linked to numerous potential health benefits, but research is still in its early stages.

Sources & references used in this article:

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults by CR Martens, BA Denman, MR Mazzo… – Nature …, 2018 –

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo … by RW Dellinger, SR Santos, M Morris, M Evans… – npj Aging and …, 2017 –

… -term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults by D Conze, C Brenner, CL Kruger – Scientific reports, 2019 –

Increased plasma tryptophan in HIV-infected patients treated with pharmacologic doses of nicotinamide by MF Murray, M Langan, RR MacGregor – Nutrition, 2001 – Elsevier

Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled … by P Simic, XFV Parada, SM Parikh… – BMC …, 2020 –

The NAD+ precursor nicotinamide riboside decreases exercise performance in rats by IA Kourtzidis, AT Stoupas, IS Gioris… – Journal of the …, 2016 – Springer

High dose nicotinamide in the treatment of necrobiosis lipoidica by S HANDFIELD‐JONES, S Jones… – British Journal of …, 1988 – Wiley Online Library

The side effects of platinum-based chemotherapy drugs: a review for chemists by R Oun, YE Moussa, NJ Wheate – Dalton transactions, 2018 –

Nicotinamide riboside—A missing piece in the puzzle of exercise therapy for older adults? by C Custodero, SK Saini, MJ Shin, YK Jeon… – Experimental …, 2020 – Elsevier