Nexium vs. Prilosec: Two GERD Treatments

Nexium (nizatidine) is a nonsteroidal antiinflammatory drug (NSAID). It works by reducing the production of prostaglandins, which are substances that cause inflammation. These substances include cyclooxygenase-2 inhibitors such as aspirin and ibuprofen, but also other NSAIDs like diclofenac and naproxen. They all work by inhibiting these enzymes.

Prilosec (duloxetine hydrochloride) is a selective serotonin reuptake inhibitor (SSRI), which means it inhibits the reabsorption of serotonin into the brain. It was developed in the 1980’s and became available in 2001. Prilosec is used mainly to treat depression, anxiety disorders, obsessive compulsive disorder, posttraumatic stress disorder and eating disorders. It does not have any known side effects when taken regularly over time.

The most common side effect of both drugs is nausea. Some people may experience stomach pain or diarrhea with prilosec. There are no known long term risks associated with taking either drug. However, some people develop a condition called serotonin syndrome, which causes symptoms including confusion, hallucinations and seizures.

If you suffer from these conditions, your doctor will probably want to monitor you closely while taking them.

Nexium is one of the best selling drugs in the United States because it can be used to treat many different conditions. It is available without a prescription and you can get it over the counter at most drug stores. It is not known whether Nexium is addictive or not because it has not been around long enough for studies to determine if it is.

Prilosec is a relatively safe drug, but it can have serious side effects if taken in large doses. It can also cause drowsiness and dizziness.

This is a hard question to answer because both drugs have their own set of advantages and disadvantages. Taken on a short term basis, both drugs can be effective in treating heartburn and acid reflux. However, taken on a long term basis, Prilosec has been found to produce fewer side effects than Nexium.

Sources & references used in this article:

Esomeprazole tablet vs omeprazole capsule in treating erosive esophagitis by CY Chen, CL Lu, JC Luo, FY Chang… – World Journal of …, 2005 –

A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole by L Olbe, E Carlsson, P Lindberg – Nature reviews drug discovery, 2003 –

Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial by JE Richter, PJ Kahrilas, J Johanson, P Maton… – The American journal of …, 2001 – Elsevier

AstraZeneca, Prilosec, and Nexium: marketing challenges in the launch of a second-generation drug by JG Conley, RC Wolcott, E Wong – Kellogg School of Management …, 2017 –

Is Esomeprazole (Nexium) More Effective than Omeprazole (Prilosec) in Reducing Heartburn and in Increasing the Rate of Esophageal Healing in Adults with … by SP Mahoney – 2011 –

A multicenter, randomized, double-blind, 8-week comparative trial of low-dose esomeprazole (20 mg) and standard-dose omeprazole (20 mg) in patients with erosive … by CJ Lightdale, C Schmitt, C Hwang… – Digestive diseases and …, 2006 – Springer

Review of esomeprazole in the treatment of acid disorders by DA Johnson – Expert opinion on pharmacotherapy, 2003 – Taylor & Francis

An overview: Current clinical guidelines for the evaluation, diagnosis, treatment, and management of dyspepsia by P Zajac, A Holbrook, ME Super, M Vogt – Osteopathic family physician, 2013 – Elsevier

Evidence‐based treatment of frequent heartburn: The benefits and limitations of over‐the‐counter medications by JW McRorie Jr, RD Gibb… – Journal of the American …, 2014 – Wiley Online Library