Metolazone (metolazone) is a drug used to treat some types of cancer. It was developed by the pharmaceutical company Bayer AG and licensed from the German Federal Institute for Risk Assessment (BfR). Metolazone is approved in Germany only for patients with advanced or metastatic melanoma, non-small cell lung cancer, and other solid tumors. The FDA has not yet approved it for any type of cancer. Metolazone is sold under several brand names: Metolase, Metadate, Metapress, and others.
Metolazone is a tablet that contains two different active ingredients: methotrexate and doxorubicin. These are both drugs used to treat certain cancers.
They work by killing cancer cells while leaving healthy cells alone. When they are combined together in the right way, they cause less damage than either one would on its own.
The combination of these two drugs is called a “combination” because it combines the effects of both drugs. It’s like combining aspirin with ibuprofen.
Metolazone is taken orally once daily, usually at bedtime. Patients take it for three months before deciding whether to continue taking it longer or stop taking it altogether.
The most common side effects of metolazone include nausea, vomiting, diarrhea, constipation, headache, cough, fatigue, bone pain, and rash. It may also increase the risk of infections.
The drug should not be taken by people who are allergic to methotrexate or doxorubicin. It may cause harm to an unborn baby and is contraindicated for women who are pregnant and those who are breastfeeding.
Metolazone is a second-generation antibiotic. It works by interfering with the formation of bacterial cell walls.
It belongs to the chemical group known as the nitroimidazoles. Metolazone is used to treat a number of different types of infections caused by bacteria, such as urinary tract infections, prostate infections, and skin infections.
Metolazone is available under the following different brand names: Apo-Mepron, Metozolv ODT, and Ozimax 500.
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Determination of metolazone in human blood by liquid chromatography with electrospray ionization tandem mass spectrometry by G Wei, S Xiao, C Liu – Journal of Chromatography B, 2007 – Elsevier
Pharmacokinetic study of single-and multiple-dosing with metolazone tablets in healthy Chinese population by X Li, R Wang, Y Liu, Y Liu, H Zheng, Y Feng… – BMC Pharmacology and …, 2017 – Springer
Simultaneous determination of metolazone and spironolactone in raw materials, combined tablets and human urine by high performance liquid chromatography by MI Walash, N El-Enany, MI Eid, ME Fathy – Analytical Methods, 2013 – pubs.rsc.org
Stability–indicating spectrofluorimetric methods for the determination of metolazone and xipamide in their tablets. Application to content uniformity testing by MI Walash, N El-Enany, MI Eid, ME Fathy – Journal of fluorescence, 2014 – Springer