Meclizine, Oral Tablet

Meclizine Side Effects:

The most common side effect of meclizine is dizziness. The drug may cause drowsiness and sleepiness at higher doses.

Some users experience nausea or vomiting after taking the drug. Other possible side effects include headache, nervousness, insomnia, dry mouth, constipation, blurred vision and stomach pain.

If you are considering using meclizine, it is best to consult with your doctor before starting any medication. You should also avoid driving or operating machinery until you have been properly tested for these activities.

If you do take the drug, use it only under medical supervision and never drive a car or operate heavy machinery while taking this drug.

What Is Meclizine?

Meclon® (meclizine) is a prescription medicine used to treat schizophrenia and other psychotic disorders. Meclon® was approved by the FDA in 1985 for the treatment of schizophrenia. According to MedlinePlus, meclizine belongs to a class of drugs called antipsychotics known as atypical antipsychotics. Atypical antipsychotics affect certain chemicals in the brain in a way that decreases psychosis.

Meclizine is also used to treat severe nausea and vomiting caused by cancer treatment, particularly chemotherapy. It can also be useful for treating nausea and vomiting during pregnancy.

Other uses for meclizine include:

Vertigo (a medical condition causing a spinning sensation)

Motion sickness

How Does Meclizine Work?

Meclizine works by affecting certain chemicals in the brain called neurotransmitters. Neurotransmitters are chemical messengers that transmit information to different parts of the brain. Meclizine blocks the action of a specific neurotransmitter called acetylcholine in the area of the brain that controls vomiting. By blocking acetylcholine, meclizine prevents nausea and vomiting caused by motion sickness or from other sources. It does not cure the conditions that cause nausea and vomiting.

Meclizine Warnings

Meclizine can increase the effects of other drugs that cause drowsiness, including alcohol, other anti-nausea drugs such as Dramamine (dimenhydrinate), narcotic pain relievers, certain antidepressants, and anesthetic agents. Meclizine may also decrease the effectiveness of other medications including blood pressure drugs and MAO inhibitors.

Talk to your doctor about any medications you are currently taking, and always let your doctor know before starting any new medication.

Greater side effects are seen at higher doses.

Meclizine is not for people with glaucoma or urinary retention.

Meclizine should not be used in children under 12 years of age.

Meclizine may cause drowsiness and can impair mental and physical abilities required for the performance of potentially hazardous tasks (such as driving). Patients should use caution when driving or operating dangerous machinery until they know how this drug affects them.

Meclizine may increase the risk of seizures in people with a history of seizures.

Meclizine Warnings (continued)

Meclizine should not be used with other drugs that cause drowsiness.

Meclizine should not be used in patients with narrow-angle glaucoma or urinary retention.

Meclizine should not be used during pregnancy or if you are breastfeeding. It may cause harm to the fetus.

Do not take meclizine with any other drugs, foods, or supplements that cause drowsiness.

Do not drink alcohol while taking meclizine.

Meclizine may make your eyes more sensitive to light. Do not drive or operate machinery until you know how this medication affects you.

Meclizine side effects include:

daytime drowsiness


slowed heart rate, breathing, or gut movement (constipation)


blurred vision

dry mouth or throat

loss of appetite

weight gain

ringing in the ears

upset stomach or throwing up.

Meclizine may cause liver damage in people with a certain genetic condition called Gilbert’s syndrome.

You should not take meclizine if you have severe or uncontrolled seizures, an obstruction of the gastrointestinal tract (stomach or intestines), narrow-angle glaucoma, or urinary retention.

Do not take meclizine if you are pregnant or breastfeeding.

Meclizine should be taken with caution by people with liver problems, depression, mania or psychosis, prostate disease, urinary problems, diabetes, low blood pressure, or heart problems.

Do not exceed the recommended dose.

Do not take meclizine if you are allergic to it or similar drugs such as anticholinergic.

Do not take meclizine with alcohol, antihistamines (such as Benadryl), pain medications (such as Tylenol), sleep medications (such as Unisom), muscle relaxants (such as Zanaflex), or seizure medications (such as Tegretol).

Do not take meclizine near bedtime.

You may experience dryness of the mouth, nose, or eyes while taking meclizine.

Meclizine should be taken with caution in the elderly because they may be more sensitive to its effects.

Pregnancy: Meclizine should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breastfeeding: It is not known if meclizine is excreted in human milk. Do not take meclizine if you are breastfeeding without first talking to your doctor.

Infants & children: Meclizine is not recommended for use in children under 12 years of age.

What other drugs could interact with this medication?

There may be an interaction between meclizine and any of the following:





amphetamines (e.g., dextroamphetamine, lisdexamfetamine)

antihistamines (e.g.

dunsed, brompheniramine, chlorpheniramine, clemastine, diphenhydramine, dimenhydrinate, triprolidine)

antipsychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)



barbiturates (e.g.

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Quantification of meclizine in human plasma by high performance liquid chromatography–mass spectrometry by Z Wang, S Qian, Q Zhang, MSS Chow – Journal of Chromatography B, 2011 – Elsevier