What Is LEO-FLAVONOID?
Lipoflavonoids are natural compounds found in plants such as: rose hips, hops, oats, rye berries and others. They have been used for centuries in folk medicine to treat a variety of conditions including diabetes mellitus (high blood sugar), arthritis, asthma and many other ailments.
The most well known use of lipoflavonoids is their ability to inhibit the growth of certain types of cancer cells. A number of studies have shown that these substances may reduce the risk or recurrence of various cancers in humans. However, there are no human clinical trials investigating whether they might prevent hearing loss from exposure to loud noise. There are several theories about why this happens but it’s not yet clear which theory is correct.
There are two main theories about how lipoflavonoids could affect hearing loss. One theory suggests that the lipoflavonoids block the activity of a protein called NF-kappaB (nuclear factor kappa B). Another theory proposes that lipoflavonoids interfere with the function of another gene called TSC2 (tumor suppressor 2) in the inner ear. Both of these genes play key roles in regulating cell proliferation and differentiation, among other things.
Preliminary studies indicate that lipoflavonoids may have a protective effect on the cochlea and spiral ganglion, possibly by protecting the cells in these regions from the breakdown of the membrane that contains potassium. This breakdown results from long-term exposure to loud noises.
ARE LIPOFLAVONOIDS SAFE?
The safety of lipoflavonoids has not been rigorously studied in human studies. It appears to be relatively safe, based on the available evidence. Some people have reported a few side effects such as upset stomach and allergic reactions. There is some evidence that the supplement can interact with some drugs such as a chemotherapy medication called irinotecan (brand name Camptosar) and mifepristone (brand name Mifeprex). It is not known whether lipoflavonoids can increase the risk of hearing loss, so people who are concerned about this should seek medical advice before taking this supplement.
WHAT DOES THE RESEARCH SHOW?
There is conflicting evidence about whether or not lipoflavonoids can prevent noise-induced hearing loss. In theory, these supplements could potentially be used to prevent noise-induced hearing loss in humans but they need to be tested under rigorous conditions. Most studies have been done in animals and the results are conflicting.
Some animal studies suggest that lipoflavonoids can prevent noise-induced hearing loss by protecting the hair cells found in the inner ear. These types of studies have been done in guinea pigs, rabbits, rats, and other animals. Other animal studies show that lipoflavonoids do not prevent hearing loss.
Sources & references used in this article:
Over‐the‐Counter Tinnitus “Cures”: Marketers’ Promises Do Not Ring True by V Vendra, Y Vaisbuch, AC Mudry… – The …, 2019 – Wiley Online Library
Better Hearing: How to Improve Hearing without a Hearing Aid and Treat Tinnitus Naturally by A Mills – 2018 – books.google.com