4 Natural Supplements That Are as Powerful as Drugs

The Benefits of Berberine:

Berberine is one of the most powerful natural supplements available today. It has been used for centuries in traditional Chinese medicine (TCM) for its many health benefits including:

Reducing blood pressure and cholesterol levels. Reduces inflammation and pain caused by arthritis, rheumatism, osteoarthritis, gout, diabetes mellitus and other inflammatory conditions.

Improves the immune system. Helps prevent cancer. May improve mental performance and concentration.

It is also known to reduce blood sugar levels, which may help with weight loss and diabetes management.

Berberine is often recommended for those suffering from depression or anxiety because it helps relieve stress and boost mood. It may even increase energy levels, but only if taken regularly over time (see dosage section).

What Is Berberine?

Berberine is a naturally occurring compound found in various plants, such as the root of the ginger plant. It is also called Turmeric Root Extract, Ginger Root Extract, Curcuma Longa and Curcuminoid. It has been used for thousands of years in TCM (traditional Chinese medicine), where it was traditionally used to treat a variety of ailments including:

Depression Depression and anxiety are common side effects when taking certain medications. Because it is known to reduce stress and anxiety, berberine can be a helpful remedy if you’re experiencing these side effects.

High cholesterol It is often used to lower cholesterol and triglyceride levels, especially in those who are at risk of heart disease.

Inflammatory bowel diseases (IBD) IBD is a group of disorders that cause inflammation of the digestive tract. It can cause severe abdominal pain, weight loss, diarrhea and more.

Berberine can be an effective remedy for IBD.

Infectious diarrhea Infectious diarrhea is caused by viruses, bacteria, parasites or other infection in the digestive system. It is very different from IBD which involves inflammation.

Metabolic syndrome Metabolic syndrome refers to a group of risk factors that increases your risk of heart disease, stroke and diabetes. These factors include obesity, high blood pressure, high cholesterol and high blood sugar.

Tuberculosis Tuberculosis is a severe lung infection caused by bacteria. It often causes a productive cough that produces mucous, and/or blood.

If untreated it can be deadly.

Neurodegenerative disorders Neurological disorders affect the brain and nervous system, and can lead to conditions like ALS, epilepsy, Parkinson’s disease and Alzheimer’s disease. These are often complex and incurable, but berberine has been shown to help prevent and reverse these conditions in animal studies.

Syphilis Syphilis is a sexually transmitted infection (STI) caused by the bacteria treponema pallidum. It has a variety of symptoms and can remain asymptomatic, but it can lead to serious complications if left untreated.

Cholera Cholera is an acute intestinal infection that causes severe diarrhea and vomiting. It leads to severe dehydration and can be deadly if not treated quickly.

It is caused by the vibrio cholera bacteria which invades the intestinal tract.

Helicobacter pylori infection (HPI) H. Pylori is a spiral shaped bacteria that naturally lives in the stomach.

If it overpopulates it can cause ulcers, or HPI. It also increases your risk of stomach and intestinal cancer. It is often referred to as “the silent killer” because 70-80% of those infected don’t realize they have it.

Eradicate intestinal worms Intestinal worms are parasites that infect the intestines. The most common type is the hookworm, which lives in feces and enters your body through dirt.

It is very rare to have an infestation of these worms, but it can be extremely dangerous in some parts of the world.

Filariasis Filariasis is a group of diseases caused by parasitic worms called lymphatic filariae. The most common types of filarial diseases are elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis).

These diseases are spread through the bite of a particular kind of mosquito.

Tularaemia Tularaemia is an infection caused by the bacteria called Rickettsia typhi. It causes fever, headaches and other flu-like symptoms.

Left untreated it can spread to the bloodstream and other parts of the body, which is very dangerous.

See how berberine fights disease

The way that berberine works to fight these diseases is by activating AMP-activated protein kinase (AMPK). This enzyme acts as a master switch that tells your body to turn on fat burning and boost your immune system.

Whenever you get sick, eat too much or just store excess fat, your AMPK levels naturally decrease. By taking berberine, you can increase your AMPK levels to boost your immune system and shed pounds almost effortlessly.

What is AMPK?

Basal metabolic rate (BMR) is a measurement of the minimum amount of energy per day that your body requires to survive. It’s essentially the lowest number of calories you need to not die. Theoretically, if you had zero physical activity and spent all day in bed, your body would require approximately BMR calories per day to survive. BMR is separate from anything related to physical activity. It also differs from your daily energy requirements since those will be higher if you do physical activity during the day or have a physically demanding job. Your BMR is largely dependent on your hormones and your lean muscle mass. That’s why people with more muscle and lower body fat have a higher BMR than those who are lean but have more body fat. Your BMR can be influenced by different factors, including your age, hormone levels, food intake, sleep patterns and your environment. A low BMR is the primary cause of weight gain and obesity. If you consume more energy than you burn, you’ll gain weight. If you consume fewer calories than you burn, you’ll lose weight.

The difference between berberine and other AMPK activators Berberine’s ability to increase AMPK and increase your BMR is why it’s so effective for weight loss and improving your metabolism. However, not all AMPK activators are created equal.

There are many other supplements that have AMPK activating effects. These include: Green tea


Gymnema Sylvestre


Salacia Reticulata Unfortunately, many of these supplements don’t work very well or aren’t as extensively researched as berberine. For this reason, it’s always best to go with the berberine supplement.

In addition, not all AMPK activators provide long-lasting effects. Some, like green tea, provide short term activation while others, like Salacia Reticulata only provide mild activation.

How to take berberine for weight loss For the best results, it’s recommended to take 500mg of berberine 2-3 times daily 30-45 minutes before meals. If you’re using it as a weight loss aid, it’s best to take 1,000mg (1 gram) 3 times per day around the same times every day.

How long does it take for berberine to work?

It typically takes anywhere from one to three months before you start to notice major changes. However, you may experience some minor changes in a few weeks. Some people report having more energy and less hunger almost immediately. Others have reported improvements after one month of use, but most people need about two months before they see major changes. Remember that not everyone is the same and some people may have a better metabolism and faster results. Fortunately, berberine is cheap and affordable so you have nothing to lose by trying it out.

Does berberine have any side effects?

When used at the right dosage, berberine is a very safe supplement with very few side effects. Most people don’t experience any side effects while taking it whatsoever. Even in high doses (several grams per day), berberine is well tolerated and safe for most people. Berberine has also been shown to be safe for long-term daily use without having any major side effects. If you experience any side effects while taking berberine, stop using it immediately. The most common side effect is diarrhea, which is why you should take berberine with meals. Other possible side effects include: Stomach pain


Cramping If you experience any of these symptoms, stop taking berberine and seek medical attention if the symptoms persist. Some people are allergic to berberine and experience anaphylactic shock, coughing or breathing difficulties.

If you’re allergic to herbs in the Berberidaceae family, you should not take this supplement.

Does berberine interact with other supplements?

While berberine is safe to use on its own, there are certain times when you should take a break from using it or not take it at all. This includes if you’re taking any of the following: Certain HIV medications



Certain blood pressure medications

Diuretics (water pills) There’s also a contraindication with berberine and vitamin K. When taking berberine, your body isn’t able to process vitamin K as efficiently.

This can cause an issue with blood clotting and ultimately increase your risk of bleeding. Because of this, it’s best to not take berberine and vitamin K at the same time. Vitamin K is typically found in leafy greens like kale, spinach and collards. It’s also in a variety of other foods like meat, milk and other dairy products. If you’re taking any of the medications listed above or you have a medical condition that requires you to take vitamin K you should talk to your doctor before taking berberine.


Berberine is a powerful supplement that can help you melt fat, improve your cholesterol and even reduce your blood sugar. It’s not a magic pill that will make you burn fat overnight, but in combination with a proper diet and regular exercise routine you should see excellent results.

It’s also one of the only supplements backed by science and research, which makes it a top choice among doctors and researchers. The only common side effects are stomach aches and diarrhea, but these are manageable and worth it if you want to lose weight.

Frequently asked questions

What are the side effects of high doses of berberine?

High doses of berberine can cause stomach aches, diarrhea and potentially more serious issues like intestinal bleeding. These symptoms can be avoided by taking berberine with food and never exceeding the recommended dosage.

How long does it take to start working?

Most people start noticing results within a week or two of consistent dosing.

Can I take berberine with other medications?

It’s safe to take berberine with most medications. However, there are a few instances where you should not combine certain supplements. These include: Certain HIV medications



Certain blood pressure medications

Diuretics (water pills) If you’re currently taking any of these, talk to your doctor before combining them with berberine.

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