Tizanidine Side Effects:
There are no known drug interactions with tizanidine. However, it is advised to consult your doctor before using any medication if you have medical conditions or take medications which may interact with each other. You should not use tizanidine if you are allergic to its active ingredient (tizanium dioxide).
If you experience any of these symptoms after taking tizanidine, stop using it immediately and consult your doctor.
Common Side Effects:
The most common side effect reported by users is dizziness. Other possible side effects include nausea, headache, diarrhea, constipation, dry mouth and insomnia. Some users report feeling lightheaded while sleeping.
You may also notice some changes in vision such as blurred vision or double vision.
It is recommended to start with a low dose of 1 mg and increase it gradually up to 10 mg daily. A typical dosage range would be 0.5 – 5 mg twice per day.
Some users report that they could take them at bedtime instead of during the daytime. It is advisable to consult your doctor before starting tizanidine if you have any medical condition or are taking medications which may interact with each other.
It is not known when tizanidine can be eliminated from the body. Since it is eliminated through the urine, it can take between 1 to 3 days for all of the medication to leave your system. You may experience headache or nausea during this time.
Check with your doctor before taking tizanidine if you are taking any prescription drugs since it may cause interactions. Some of the drugs which may interact with tizanidine include ciprofloxacin, sumatriptan, ergotamine, lysergic acid diethylamide (LSD), tramadol, propoxyphene, pentazocine and hydrocodone.
The usual dosage is 1 to 10 mg, one to three times a day. Your doctor will prescribe the exact dosage that is right for you. Tizanidine can be taken with or without food.
Tizanidine is a muscle relaxant used to treat muscle spasms associated with a range of conditions, including multiple sclerosis and injuries of the spinal cord. It is also used to treat painful muscle spasms in the bladder (interstitial cystitis). Tizanidine is supplied in 10mg tablets for sublingual (under the tongue) use only.
Tizanidine is used to treat spasms of the muscles in the bladder and urinary tract (urinary spasm). It relaxes the muscles in these organs, and helps to eliminate your symptoms such as pain or burning when you urinate, and urine leakage. Tizanidine can also be used to treat spasms in the colon (rectal spasm).
Tizanidine can be used short-term to treat these symptoms, or long-term as maintenance therapy to prevent recurring muscle spasms. Tizanidine is in a class of drugs called centrally acting antispasmodic drugs. It works by stopping nerve signals to the muscles, which prevents the spasms.
Tell your doctor if you have any serious medical conditions, such as myasthenia gravis, a certain heart rhythm disorder, or problems with your thyroid. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Tizanidine may affect the way other medicines work, and other medicines may affect how tizanidine works. Using tizanidine with drugs that cause sleepiness or drowsiness may cause side effects.
Tizanidine may cause drowsiness, dizziness, lightheadedness, or trouble concentrating. Make sure you know how you react to it before you drive, use machinery, or do anything else that could be dangerous if you are not alert.
Do not take tizanidine with alcohol, antihistamines, barbiturates, or other drugs that cause drowsiness. These can also cause low blood pressure and slow your breathing.
Take tizanidine exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Tizanidine may be taken with or without food. Swallow tizanidine tablets whole; do not split, chew, or crush them.
Do not stop using tizanidine suddenly or you could have unpleasant withdrawal symptoms.
Sources & references used in this article:
Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets by G Shanker, CK Kumar, CSR Gonugunta, BV Kumar… – AAPS …, 2009 – Springer
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury by L Kamen, HR Henney III, JD Runyan – Current medical research …, 2008 – Taylor & Francis
Formulation, evaluation and optimization of fast dissolving tablet containing tizanidine hydrochloride by PS Zade, PS Kawtikwar, DM Sakarkar – Int J Pharm Tech Res, 2009 – Citeseer