Leflunomide, Oral Tablet

Leflunomide Side Effects:

The following are some of the most common side effects associated with Leflunomide. These include:

Dizziness (drowsiness)

Dizziness (drowsiness) is one of the main side effects of Leflunomide. Some people experience dizziness only while taking this medication.

Other people report dizziness when they stop taking this medication. Dizziness is usually temporary and does not require any treatment. If you have had a seizure or another seizure-like condition, it could cause you to lose consciousness and fall down from your chair or bed. You should avoid driving or operating machinery until the effect of this medication wears off completely.

Headache

Some people experience headaches while on Leflunomide. Headaches are usually mild and do not require any treatment.

However, if you have migraine headaches, you should avoid using Leflunomide.

Nausea/Vomiting

Some people experience nausea while on Leflunomide. Nausea is generally mild and does not need to be treated.

If you feel nauseous, you should avoid drinking alcohol or eating foods containing milk products until the effect of this medication wears off completely. If you vomit soon after taking this medication, take another dose. Otherwise, do not take a second dose.

Hair Loss

For some people Leflunomide causes temporary hair loss. This effect is usually only noticed when the pill is taken and only lasts for a short period of time.

Kidney Disease/Failure

If you have or have ever had kidney disease or failure, your doctor will most likely not prescribe Leflunomide. Be sure to tell your doctor if you have ever had kidney disease or failure.

Liver Disease

People with liver disease are more likely to have complications when taking Leflunomide. You should avoid taking this medication if you have liver disease.

Stomach or Intestinal Disease

People with stomach or intestinal disease can have complications when taking Leflunomide. You should avoid taking this medication if you have stomach or intestinal disease.

Sources & references used in this article:

Clinical pharmacokinetics of leflunomide by B Rozman – Clinical pharmacokinetics, 2002 – Springer

Formulation and in-vitro evaluation of leflunomide oral tablet with enhanced dissolution by AA Ammar, SA Eladawy, GH Elosaily… – Journal of American …, 2015 – researchgate.net

Treatment of patients with juvenile rheumatoid arthritis with combination of leflunomide and methotrexate by JS Gao, H Wu, J Tian – Zhonghua er ke za zhi= Chinese journal of …, 2003 – europepmc.org

… risks of leflunomide(Arava™); A pyrimidine synthesis inhibitor: counseling women taking leflunomide before or during pregnancy and men taking leflunomide … by RL Brent – Teratology, 2001 – jdc.jefferson.edu

Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double‐blind, randomized, placebo‐controlled clinical trial by JP Kaltwasser, P Nash, D Gladman… – … : Official Journal of …, 2004 – Wiley Online Library

Enhancement of dissolution behavior of antiarthritic drug leflunomide using solid dispersion methods by TV Volkova, GL Perlovich, IV Terekhova – Thermochimica Acta, 2017 – Elsevier

Comparative bioequivalence study of leflunomide tablets in Indian healthy volunteers by S Agarwal, A Das, D Ghosh, AK Sarkar… – …, 2012 – thieme-connect.com

Leflunomide improves psoriasis in patients with psoriatic arthritis: an in-depth analysis of data from the TOPAS study by P Nash, D Thaçi, F Behrens, F Falk, JP Kaltwasser – Dermatology, 2006 – karger.com