Fludrocortisone (also known as: Fosinopril) is a synthetic corticosteroid drug which was developed in the late 1960’s and early 1970’s. It is used primarily for treatment of asthma, allergic rhinitis, and other inflammatory conditions. It works by inhibiting cyclooxygenase enzymes involved in inflammation and pain production. However it does not have any significant effect on normal tissue or organs such as the brain or heart. Its main use is to treat patients with severe asthma.
The dosage of fludrocortisone varies from patient to patient depending on their medical condition, age, weight, and other factors. Most commonly prescribed doses range between 1mg and 2 mg per day.
There are no long term studies done on fludrocortisone in humans yet so there is no way of knowing how much it will actually affect your body over time.
Side Effects of Fludrocortisone
Fludrocortisone is considered safe when taken appropriately. Side effects include: nausea, vomiting, headache, dizziness, insomnia, muscle aches and pains.
The most common side effect is the one mentioned above. Other possible side effects include: blurred vision; loss of appetite; fatigue; increased urination; decreased blood pressure; chest pain or discomfort; diarrhea or constipation; changes in menstrual cycle. In some rare cases, you may experience breathing difficulties or break out in a rash. In any of these cases you are encouraged to seek medical attention immediately.
Fludrocortisone is not safe for everyone: people with a known hypersensitivity (allergy) to fludrocortisone, other corticosteroids or any of the inactive ingredients should not take this drug as an allergic reaction may be fatal.
Sources & references used in this article:
Stability of fludrocortisone acetate solutions prepared from tablets and powder by S Cisternino, J Schlatter, JL Saulnier – European journal of pharmaceutics …, 2003 – Elsevier
Antagonism of fludrocortisone by spironolactone and canrenone. by GJ Huston, P Turner – British journal of clinical pharmacology, 1976 – ncbi.nlm.nih.gov
Hydrocortisone plus fludrocortisone for adults with septic shock by D Annane, A Renault, C Brun-Buisson… – … England Journal of …, 2018 – Mass Medical Soc
Fludrocortisone does not prevent orthostatic hypotension in astronauts after spaceflight by SJ Shi, DA South, JV Meck – Aviation, space, and …, 2004 – ingentaconnect.com
Hydrocortisone suspension and hydrocortisone tablets are not bioequivalent in the treatment of children with congenital adrenal hyperplasia by DP Merke, D Cho, K Anton Calis, MF Keil… – The Journal of …, 2001 – academic.oup.com
A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome by PK Peterson, A Pheley, J Schroeppel… – Archives of Internal …, 1998 – jamanetwork.com