Antithyroglobulin Antibody Test

Antithyroglobulin (AT) Antibody Test: Thyroid Cancer Symptoms?

The thyroglobulin antibody test is used to diagnose thyroid cancer. A positive result indicates that the patient has high levels of thyroglobulin antibodies. These antibodies are produced when the body’s immune system attacks the thyroid gland, which produces hormones like T4 and T3. High levels of these antibodies indicate that the thyroid is under attack from an external source.

Treatment options include surgery to remove the affected area or radiation therapy. Surgery may be necessary if there are no other treatment options available. Radiation therapy may be needed if the tumor cannot be removed surgically due to its location or size. If the patient does not have any other treatments, then they will likely undergo surgery and radiation therapy together.

How Does Thyroglobulin Test Work?

Thyroglobulin antibody tests work by detecting the presence of thyroglobulin antibodies. Thyroglobulin is a protein found in the thyroid gland. When this protein is present, it means that the thyroid gland is producing enough hormones to keep up with metabolism. However, when there are too many proteins present in the thyroid gland, it can cause problems such as hyperthyroidism or goiters.

Tests that detect antithyroglobulin antibodies are used to find possible causes of hyperthyroidism:

If the body is attacking the patient’s own thyroid tissue. The most common reason is that bodies don’t produce enough thyroid-stimulating hormone (TSH). For this reason, antithyroglobulin antibody tests are often given to people with overactive thyroids to see if their bodies are laying waste to their own body tissue.

If the bodies are being attacked by external forces such as a virus, bacteria, or other pathogen.

If the body is experiencing an allergic reaction to a drug or other substance.

What Are the Different Types of Antithyroglobulin (AT) Antibody Test?

There are two types of antithyroglobulin antibody tests that are used to detect the presence of antithyroglobulin antibodies in the blood:

IgG Antibody Test: The immunoglobulin G (IgG) type of antithyroglobulin antibody test is most commonly used to detect the presence of antithyroglobulin antibodies in patients who have thyroid nodules or an overactive thyroid.

Thyroglobulin Antibody Test: The thyroglobulin antibody test is used to find out whether or not a patient has had an allergic reaction to a drug or any other type of substance.

What Do the Antithyroglobulin Antibody Test Results Mean?

A positive antithyroglobulin antibody test result will mean that there are antithyroglobulin antibodies in the blood.

Sources & references used in this article:

The pathogenic role of anti‐thyroglobulin antibody on pregnancy: evidence from an active immunization model in mice by ST Matalon, M Blank, Y Levy, HJA Carp… – Human …, 2003 –

Cytophilic antithyroglobulin antibody and antibody-dependent monocyte-mediated cytotoxicity in Hashimoto’s thyroiditis by S SUZUKI, M MITSUNAGA, M MIYOSHI… – The Journal of …, 1980 –

Correlation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease by BA Baker, H Gharib, H Markowitz – The American Journal of Medicine, 1983 – Elsevier

Clinical significance of elevated level of serum antithyroglobulin antibody in patients with differentiated thyroid cancer after thyroid ablation by JK Chung, YJ Park, TY Kim, Y So, SK Kim… – Clinical …, 2002 – Wiley Online Library

Increased sensitivity of a new assay for anti-thyroglobulin antibody detection in patients with autoimmune thyroid disease by R Sapin, M d’Herbomez, F Gasser, L Meyer… – Clinical …, 2003 – Elsevier

High prevalence of anti-phospholipid antibodies and anti-thyroglobulin antibody in patients with hepatitis C virus infection treated with interferon-α. by J Matsuda, N Saitoh, M Gotoh… – American Journal of …, 1995 –

Sequential changes of serum antithyroglobulin antibody levels are a good predictor of disease activity in thyroglobulin-negative patients with papillary thyroid … by CJ Hsieh, PW Wang – Thyroid, 2014 –